There are a lot of tough spots in limit hold’em. One of the toughest is dealing with river raises. Your hand is strong enough that you feel that you should bet it for value, but then you get raised. For a lot of players, the default behaviour here is to call the raise. You are usually being offered good odds, so you figure, even if you’re probably beat, the few times you catch a bluff will be enough to balance everything out. There are certainly other factors that come into play here besides the size of the pot. What kind of player the raiser is, as well as the texture of the board play a big role in the decision.
Below is a graph which describes the results of bet/calling the river over a sample of 464 hands. The two strategies compared were “Call” which is the strategy actually employed, and “Fold” which picks the hypothetical option of folding. The line tracks a moving average of the resulting net earn as a function of the hand strength.

One thing that struck me was just how strong your hand needs to be to make more money than folding. In the games sampled, it took a hand strength greater than .87 to make calling down preferable to folding. That corresponds roughly to top pair top kicker on a not-to-threatening board. AKo on a board of KJT32 has a linear strength of .877, beating or tying 87.7% of all possible hands.
When you are faced with a river raise, calling is clear when you have a hand which beats top pair top kicker. If you have a hand which is worse than TP/TK, then you need to strongly consider how likely the player is to be bluffing and pot size. Any legitimate hand that raises your medium hand will almost certainly beat you, so bluff beating becomes the primary facter in determining whether you should call.